Uncover the Astrocyte Profile in Alzheimer’s Disease

 

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that impairs cognitive function and interferes with the ability to carry out normal daily tasks. The two most common pathological hallmarks of AD are the generation of toxic amyloid beta (Aβ) peptides and their accumulation in amyloid plaques, and hyperphosphorylation of Tau protein leading to the formation of Tau tangles. These events compromise neuronal cell health and ultimately lead to cell death. While tremendous progress has been made in understandisung the underlying molecular mechanisms leading to neuronal loss, it is unclear how non-neuronal cells, such as astrocytes, may contribute to disease pathology or progression. In recognition of Alzheimer’s Awareness Month, we are highlighting a recent study that characterizes the cellular landscape of AD by defining the genome and proteome of disease-associated astrocytes. 

 

Featured Antibodies for Alzheimer's Research
Specificity Clone Reactivity  Application
APP, Aβ peptides 6E10 Human IHC-P, WB, ELISA
APP, Aβ peptides M3.2 Mouse, Rat WB, ELISA
Aβ 1-42 12F4 Human, Mouse, Rat IHC-P, WB, ELISA
Aβ 1-40 11A50-B10 Human, Mouse, Rat IHC-P, WB
α-Synuclein, aggregated A17183A Human IHC-P
Aggregated Aβ A17171C Human IHC-P, WB
Aggregated Aβ 3A1    
APP/Aβ Antibody Sampler Kit 6E10, 12F4, 3A1, M3.2, 11A50-B10 Human, Mouse, Rat IHC-P, WB, ELISA
Tau Phospho (Ser262) A15091A Human IHC-P, WB, ELISA
Tau, 1-223 A16103A Human IHC-P, WB, ELISA
Tau, 368-441 A16097F Human IHC-P, WB, ELISA
Tau Phospho (Thr181) M7004D06 Human IHC-P, WB, ELISA
Tau Antibody Sampler Kit A15091A, A16103A, A16097F, M7004D06 Human IHC-P, WB, ELISA
GFAP SMI 24 Human, Mouse, Rat IHC-P, WB
GFAP SMI 25 Human, Mouse, Rat IHC-P, WB
ALDH1L1 N103/39 Human, Mouse WB
Glutamine Synthetase O91F4 Human, Mouse, Rat IHC-P, ICC, WB
Glial Cell Marker Antibody Sampler Kit 8E10.D9, S1600D, SMI 24, SMI 91, P82H9 Human, Mouse, Rat IHC-P, WB

References:

  1. Keren-Shaul et al. A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease. Cell. 2020; 169 (7): P1276-1290.
  2. Habib et al. Disease-associated astrocytes in Alzheimer’s disease and aging. Nature Neuroscience. 2020; 23: 701-706.
  3. Oakley et al. Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation. J Neurosci. 2006; 26 (40): 10129-10140.
  4. Matias et al. Astrocyte Heterogeneity: Impact to Brain Aging and Disease. Front Aging Neurosci. 2019; 11; 59.
  5. Rodriguez-Arellano et al. Astrocytes in physiological aging and Alzheimer’s disease. Neuroscience. 2016; 323; 170-182.

 

 

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