Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that impairs cognitive function and interferes with the ability to carry out normal daily tasks. The two most common pathological hallmarks of AD are the generation of toxic amyloid beta (Aβ) peptides and their accumulation in amyloid plaques, and hyperphosphorylation of Tau protein leading to the formation of Tau tangles. These events compromise neuronal cell health and ultimately lead to cell death. While tremendous progress has been made in understandisung the underlying molecular mechanisms leading to neuronal loss, it is unclear how non-neuronal cells, such as astrocytes, may contribute to disease pathology or progression. In recognition of Alzheimer’s Awareness Month, we are highlighting a recent study that characterizes the cellular landscape of AD by defining the genome and proteome of disease-associated astrocytes.
Featured Antibodies for Alzheimer's Research | |||
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Specificity | Clone | Reactivity | Application |
APP, Aβ peptides | 6E10 | Human | IHC-P, WB, ELISA |
APP, Aβ peptides | M3.2 | Mouse, Rat | WB, ELISA |
Aβ 1-42 | 12F4 | Human, Mouse, Rat | IHC-P, WB, ELISA |
Aβ 1-40 | 11A50-B10 | Human, Mouse, Rat | IHC-P, WB |
α-Synuclein, aggregated | A17183A | Human | IHC-P |
Aggregated Aβ | A17171C | Human | IHC-P, WB |
Aggregated Aβ | 3A1 | ||
APP/Aβ Antibody Sampler Kit | 6E10, 12F4, 3A1, M3.2, 11A50-B10 | Human, Mouse, Rat | IHC-P, WB, ELISA |
Tau Phospho (Ser262) | A15091A | Human | IHC-P, WB, ELISA |
Tau, 1-223 | A16103A | Human | IHC-P, WB, ELISA |
Tau, 368-441 | A16097F | Human | IHC-P, WB, ELISA |
Tau Phospho (Thr181) | M7004D06 | Human | IHC-P, WB, ELISA |
Tau Antibody Sampler Kit | A15091A, A16103A, A16097F, M7004D06 | Human | IHC-P, WB, ELISA |
GFAP | SMI 24 | Human, Mouse, Rat | IHC-P, WB |
GFAP | SMI 25 | Human, Mouse, Rat | IHC-P, WB |
ALDH1L1 | N103/39 | Human, Mouse | WB |
Glutamine Synthetase | O91F4 | Human, Mouse, Rat | IHC-P, ICC, WB |
Glial Cell Marker Antibody Sampler Kit | 8E10.D9, S1600D, SMI 24, SMI 91, P82H9 | Human, Mouse, Rat | IHC-P, WB |
References:
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